I'm currently in the process of installing Trac on my Dreamhost account and came across the problem, that the server doesn't allow me to work with Aliases and ScriptAliases in .htaccess files. So I had to go back to using symlinks and RewriteRules.
The problem here now seems to be, that if you for example have a dispatch.fcgi in your htdocs, all your URLs will look for example like this: http://domain/path/dispatch.fcgi/wiki.